(BT05559)TRANSPORT PHENOMENA IN BIOPROCESS

UNIT-I : Momentum transfer:
Momentum transfer in bioprocess, comparison with other transport processes, effect of flow
properties in momentum transfer and oxygen mass transfer.
UNIT-II: Oxygen transport-I
Oxygen transport to microbial cultures- Gas liquid mass transfer fundamentals, oxygen requirement
of microbial cultures. Oxygen requirements of microbial cultures oxygen mass
transfer fundamentals. oxygen transfer and oxygen demand.
UNIT-III : Oxygen transport-II
Oxygen transfer by aeration and agitation. Determination of oxygen mass transfer coefficient
by various methods including dynamic gassing out and oxygen balance methods
UNIT-IV : Momentum transport by agitation:
Power requirements and mixing characteristics of ungassed and gassed systems. Concept
of power number, use of monographs. Defining impeller Reynolds number for Newtonian
and non-Newtonian fluids. Concept of aeration rate to calculate impeller power requirement
of gassed systems.
UNIT-V: Mixing
Mixing and bioreaction interactions – Flow regimes with and without baffles, various types of
impellers and mixing equipment.
UNIT-VI : Scale-up
Scale-up criteria for mixing equipment. Application of mixing in bioprocessing.
UNIT-VII : Heat Transfer-I
Various modes of heat transfer, viz., conduction convection and radiation. Mechanism of
heat transfer by conduction, Fourier’s law. Conductive heat transfer through a series of
resistances.
UNIT-VIII : Heat Transfer-II
Analogy between heat, mass and momentum transfer. Application of heat transfer in
bioprocessisng.
TEXT BOOKS :
1. Introduction to Biochemical Engineering, D.G.Rao, Tata Mc Hill (2005)
2. Bioprocess Engineering Principles Paul M. Doran, Academic press (1995).
REFERENCES
1. “Biochemical Engineering fundamentals “2nd edition by J E Bailey and D F Ollis, Mc
Graw-Hill (1986).
2. “Biochemical Engineering” by S Aiba, A E Humphrey and N Millis, Prentice- Hall (1978).
3. Bio process Engineering : Basic concepts” 2nd ed., Michaeln L shuler and F Kargi,
Prentice Hall of India (2003).