(BT05078) BIOCHEMICAL REACTION ENGINEERING

UNIT I:
Ideal reactors:
Concept of ideal reactors based on flow characteristics, design of ideal reactors
using material and energy balance equations. Single reactors, with ideal flow
condition, comparison of volumes of plug flow reactor and chemostat. Multiple
reactors-methods to show how total volume is affected in multiple reactors.
Unit II:
Kinetics of homogeneous reactions - I
Searching for mechanism – Arrhenius equation – Batch reactor analysis for kinetics.
(synchronous growth and its application in product production).
UNIT III: Kinetics of Homogeneous reactions- II
Growth Kinetics: Batch growth quantifying cell concentration, growth profiles and
kinetics in batch culture, fed batch growth, continuous growth and their growth kinetic
quantification, chemostat growth, semi-continuous / exponential feeding strategy.
UNIT IV: MULTIPLE REACTIONS
Parallel, series and series – parallel reactions-effect of thermodynamic parameters
on the yield/selectivity of the desired product. Maximizing the yield of intermediate
product in series reactions
UNIT V :
Design principles – Non isothermal reactions and pressure effects
UNIT VI:
Non-ideal flow in bioreactors-reasons for non-ideality, concept of RTD studies,
characterization of non-ideality using RTD studies, various distribution functions,
conversions using tracer studies. Diagnosing the ills of non ideal bioreactors, various
models of non ideal flow.
UNIT VII:
Design and analysis of bioreactors-stability and analysis of bioreactors, biomass
production and effect of dilution rate.
UNIT- VIII:
Design and operation of various bioreactors, viz CSTF, fed batch systems, air-liftbioreactors,
fluidized bed bioreactors. Scale up of bioreactors. Criteria for selection
of bioreactors.
TEXT BOOKS:
1. Introduction to Biochemical Engineering, D.G.Rao, Tata Mc Hill (2005)
2. Biochemical Engineering Fundamentals, 2nd edition, Bailey, J. E. and Ollis,
D.F., Mc Gra- Hill.(1986)
REFERENCES:
1. H. Scott Fogler, Elements of Chemical Reaction Engineering, II Edition, Prentice
Hall of India Pvt. Ltd.
2. O.Levenspial, Chemical Reaction Engineering, Wiley Eastern, III ed, New Delhi.
3. Charles D. Holland, Fundamentals of Chemical Reaction Engineering, John
Wiley and Sons, 1990.
4. J.M. Smith, Chemical Engineering Kinetics, Mc Graw Hill, 1981.