(BT05112) CANCER BIOLOGY

Unit I: Fundamentals of Cancer Biology
Regulation of Cell cycle, mutations that cause changes in signal molecules, effects
on receptor, signal switches,
Unit II: Tumor Suppression
tumour suppressor genes, modulation of cell cycle in cancer. Different forms of
cancers, Diet and cancer.
Unit III: Principles of Carcinogenesis I
Chemical Carcinogenesis, Metabolism of Carcinogenesis, Natural History of
Carcinogenesis, Targets of Chemical Carcinogenesis
Unit IV: Principles of Carcinogenesis II
Principles of Physical Carcinogenesis, X - Ray radiation - mechanism of radiation
Carcinogenesis.
Unit V: Molecular Cell Biology Of Cancer
Oncogenes, Identification of Oncogenes, Retroviruses and Oncogenes, detection
of Oncogenes, Growth Factor and Growth Factor receptors that are Oncogenes.
Oncogenes / Proto Oncogene activity. Growth factors related to transformations.
Unit VI: Principles of Cancer Metastasis
Clinical significances of invasion, heterogeneity of metastatic phenotype, Metastatic
cascade, Basement Membrane disruption, Three-step theory of Invasion,
Proteinases and tumour cell invasion.
Unit VII: Detection of Cancer
Detection of Cancers, Prediction of aggressiveness of Cancer, Advances in Cancer
detection.
Unit VIII: New Molecules for Cancer Therapy
Different forms of therapy, Chemotherapy, radiation Therapy, and Immuno therapy:
advantages and limitations.
TEXT BOOKS
1. Maly B.W.J. Virology a practical approach, IRL Press, Oxford, 1987.
2. Dunmock N.J and Primrose.S.B., Introduction to modern Virology, Blackwel
Scientific Publications. Oxford, 1988.
REFERENCE:
1. An Introduction to Cellular and Molecular Biology of Cancer, Oxford Medical
publications, 1991.