(BT05095) BIOPHARMACEUTICAL TECHNOLOGY

Unit I: Introduction to Pharmaceuticals
History & Definition of Drugs. Sources of Drugs - Plant, Animals, Microbes and Minerals.
Different dosage forms. Routes of drug administration.
Unit II: Pharmacodynamics
Physico-Chemical Principles, Pharmacodynamics- Mechanism of drug action, drug receptors,
and Physiological receptors: structural and functional families.
Unit III: Pharmacokinetics
Pharmacokinetics- Drug absortion, factors that affect the absortion of drugs, Distribution of
drugs, Biotransformation of drugs, Bioavailability of drugs.
Unit IV: Drug manufacturing processes I
Good manufacturing practices, manufacturing facilities, sources of Biopharmaceuticals,
Unit V: Drug manufacturing processes II
Production & analysis of Biopharmaceuticals.
Unit VI: Production of Biopharmaceuticals
Production of Therapeutic Proteins, Hormones, Cytokines - Interferons, Interleukins I & II,
Tumor Necrosis Factor (TNF); Nucleic acids.
Unit VII: Applications of Biopharmaceuticals
Role of Biopharmaceuticals in treatment of various health disorders
Unit VIII: Drug Delivery Systems, Biomaterials and their Applications
Controlled and sustained delivery of drugs. Biomaterial for the sustained drug delivery.
Liposome mediated drug delivery. Drug delivery methods for therapeutic proteins.
Reference:
1. Biopharmaceuticals: Biochemistry & Biotechnology, Gary Walsh (1998), John Wiley &
Sons Ltd.
2. Remington’s Pharmaceutical sciences, Mark Publications & Co.
3. Theory & Practice of Industrial Pharmacy, (3rd ed.) Leon Lachman, Lea &
Febiger (1986)