(BT05304) IMMUNOLOGY

Unit I: The Immune System
Introduction, Phylogeny of the Immune system, Innate and acquired immunity.
Immunochemistry: Immunogens, antigens, their chemical nature, Properties
influencing immunogenicity, Haptens, adjuvants.
Unit II: Biology of the Immune System
Cells of the IS: Haematopoiesis, lymphocyte leafficking, T, B, Macrophases,
Dendritic cells, Natural killer cells, Eosinophils, Neutrophils, Mast cells and
Phasocylosis.
Unit III:
Organs of the I.S. : Primary and Secondary organs of I.S. (Thymus, Spleen,
Lymphnode, lymphoid fo kicle, MALT, CALT, SALT
Unit IV: Humoral Immunity-I
B-lymphocytes, their lineage, Immunoglobulins, their structure function, classes,
sub classes, genetic control of ab production. (Maturation of B cell) Isotype, allotypes,
Idiotypes.
Unit V: Humoral Immunity -II
Activation of B cells, their differentiation and effector functions. Hybridoma
Technology Monoclonal antibodies their application. Immunotoxing chimeric
antibodies and abzymes.
Unit VI: Cell mediated Immunity
T-cells subclasses their lineage, maturation TCR diversity, MHC, Ag processing
and presentation, T-cell artivation, effector functions.
Unit VII: Antigen-Antibody interactions and their significance in diagnosis and
Hypersensitivity,
Unit VIII: Tumor Immunology
Transplantation- Graft rejection evidence and mechanisms of graft rejection
,prevention of graft rejection, immuno suppressive drugs, Autoimmunity –
experimental models of autoimmune disease treatment of autoimmune disorders
and Tumor immunology.
TEXT BOOKS:
1. Riovett. Essential Immunology, Vaccines conventional, subunit and
recombinant, antidiotypic vaccine, Blackwell Scientific publications, Oxford,
1991.
REFERENCES:
1. Benjamin E and Leskowitz S, immunology A short Course. Wiley LISS NY,
1991.ELISA Immunological Techniques. DNA vaccines Immunotechnology
2. Cellular Molecular Immunology. Abul Abbas and Litchman. 2003.
3. Kuby Immunology, 5th Edition . Richard A Goldsby, Thomas J Kindt Barbara A
Osborne . W H Freeman and Company.