(BT05416) MOLECULAR PATHOGENESIS

UNIT I: INTRODUCTION
Introduction to pathogenesis, components of microbial pathogenicity. Population genetics of Microbial
pathogenesis, methods to detect genetic diversity and structure in nature population, epidemiology, cryptic
diseases.
UNIT II: HOST DEFENCES I
Host defense against pathogens, clinical importance of understanding host defense, components of the
host surface defences systems like skin, mucosa, eye, mouth, respiratory tract.
UNITIII: HOST DEFENCES II
Components of the systemic defense like the tissues and blood.
UNIT IV HOST- PATHOGEN INTERACTION
Virulence and virulence factors, colonising virulence factors, virulence factors damaging the host tissues,
virulence genes and regulation of the virulence genes.
UNIT V: EXPERIMENTAL METHODS
Experimental methods to study host-pathogen interaction, selecting the pathogen model, measurement of
virulence, identification of potential virulence factors,
UNIT:VI MODULATION OF IMMUNE RESPONSE
modulation of immune response by vaccines, properties of vaccines, other immuno modulators.
UNIT VII: PARADIGMS OF PATHOGENESIS:
Diphtheria disease by colonisation; Disease without colonisation, Clostridium botulinum and Staphylococcus
aureus; Intestinal infections, Shigella and E.coli infections; Vibrio cholera Salmonella infections; fungal
infections
UNIT VIII: FUTURE CHALLENGES
Gastric and duodenal ulcers - are they due to infections? Lyme disease and Syphilis - unsolved mystery.
Legionnaires disease-aftermath of comforts.Tuberculosis and other mycobacterial infections reemerging
with vengeance. Rheumatic fever and glomerulo nephritis - still a question to be solved.
TEXT BOOKS:
1. Iglewski B.H. and Clark V.L. Molecular basis of Bacterial pathogenesis, Academic press, 1990.
2. Janeway C.A. Jr, and Travers P. T. Immunobiology. Blackwell J Scientific Publishers, 1994.
REFERENCES:
1. Talaro K. and Talaro A. Foundations in Microbiology, W.C. Brown Publishers, 1993.
2. Roitt I. Essentials of Immunology, 8th edition, Blackwell Scientific Publishers, 1994.
3. Austyn J.M. and Wood K.J. Principles Cellular and Molecular Immunology,
OxfordUniversityPress,1993.