JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY
HYDERABAD
B.TECH. BIO-TECHNOLOGY
I Year
CS05143 Computer Programming for Biotechnologists 3+1* - 6
HS05231 English 2+1* - 4
EE05066 Basic Electrical and Electronics Engineering 3+1* - 6
BT05273 Fundamentals of Biology 4+2* - 8
MA05367 Mathematics for Biotechnologists 3+1* - 6
BT05483 Process Engineering Principles 3+1* - 6
ME05230 Engineering Workshop Practice - 3 4
CS05144 Computer Programming Lab - 3 4
EE05067 Basic Electrical and Electronics Engineering Lab - 3 4
HS05232 English Language Communication Skills Lab - 3 4
ME05220 Engineering Drawing Practice Lab - 3 4
II Year I Semester
BT05080 Biochemistry 4+1* - 4
BT05079 Biochemical Thermodynamics 4+1* - 4
BT05113 Cell Biology 4+1* - 4
BT05276 Genetics 4+1* - 4
BT05402 Microbiology 4+1* - 4
BT05559 Transport Phenomena in Bio Process 4+1* - 4
BT05081 Biochemistry Lab - 3 2
BT05114 Cell Biology And Microbiology Lab - 3 2
II Year II Semester
BT05096 Bioprocess Engineering 4+1* 4
CE05239 Environmental Studies 4+1* 4
BT05319 Instrumental Methods of Analysis 4+1* 4
HS05353 Managerial Economics and Financial Analysis 4+1* 4
BT05413 Molecular Biology 4+1* 4
MA05476 Probability and Statistics 4+1* 4
BT05097 Bioprocess Engineering Lab -I 3 2
BT05320 Instrumental Methods of Analysis Lab 3 2
III Year I Semester
BT05078 Biochemical Reaction Engineering 4+1* 4
BT05071 Basic Industrial Biotechnology 4+1* 4
BT05234 Environmental Biotechnology 4+1* 4
BT05275 Genetic Engineering 4+1* 4
BT05354 Mass Transfer and Separation 4+1* 4
BT05454 Plant Biotechnology 4+1* 4
BT05414 Molecular Biology And Genetic Engineering Lab 3 2
BT05455 Plant Tissue Culture Lab 3 2
III Year II Semester
BT05084 Bioinformatics 4+1* 4
BT05240 Enzyme Engineering 4+1* 4
BT05286 Heat Transfer in Bioprocesses 4+1* 4
BT05325 Instrumentation and Process Control 4+1* 4
BT05304 Immunology 4+1* 4
BT05502 Regulatory Affairs and Clinical Trials 4+1* 4
BT05098 Bioprocess Engineering Lab-II 3 2
BT05305 Immunology Lab 3 2
IV Year I Semester
BT05134 Computational Molecular Biology 4+1* - 4
BT05076 Bio Ethics, Bio Safety And Intellectual Property Rights 4+1* - 4
BT05099 Biosensors and Bioelectronics 4+1* - 4
BT05181 Downstream Processing 4+1* - 4
ELECTIVE –I 4+1* - 4
BT05100 Biotechnology for Crop Improvement
BT05112 Cancer Biology
BT05533 Structural Biology
ELECTIVE –II 4+1* - 4
BT05155 Creativity Innovation and Product Development
BT05416 Molecular Pathogenesis
BT05383 Metabolic Engineering
BT05085 Bioinformatics Lab 3 2
BT05182 Downstream Processing Lab 3 2
IV Year II Semester
BT05041 Animal Cell Science and Technology 4+1* - 4
ELECTIVE –III 4+1* - 4
BT05262 Food Science and Technology
BT05415 Molecular Modeling and Drug Design
BT05077 Bio Process Economics And Plant Design
ELECTIVE –IV 4+1* - 4
BT05095 Biopharmaceutical Technology
BT05453 Phytochemicals and Herbal Medicine
BT05426 Neuro Biology & Cognitive Sciences
CA05315 Industry Oriented Mini Project 2
CA05495 Project Work 12
CA05515 Seminar 2
Saturday, December 8, 2007
Friday, November 30, 2007
(BT05426) NEUROBIOLOGY AND COGNITIVE SCIENCES
Unit I: Introduction To Nervous Systems
Central and Peripheral nervous systems
Unit II: Neuro Anatomy I
Structure and functions of neurons, synapse. their function, signals produced by
neurons, sensors function, Glial cells,
Unit III: Neuro Anatomy II
Molecular and cellular organization of neuronal differentiation, characterization of
neuronal cells.
Unit IV: Neurophysiology
Conduction of impulses by neurons, Correlation of sensory functions.
Unit V: Neuropharmacology
Pharmaceutical mediator, released by neurons. Hormones and their effect on
neuronal function.
Unit VI: Neurological Disorders
Pathogenesis, Genetic basis of neurological disorders
Unit VII: Behavioural Science I
Neuronal mechanism of behaviour,
Unit VII: Behavioural Science II
Animal behaviour, Behaviour in various environments.
Reference:
1. A.B. Schiebel Neurobiology of higher cognitive function Guilford Press 1990,
Central and Peripheral nervous systems
Unit II: Neuro Anatomy I
Structure and functions of neurons, synapse. their function, signals produced by
neurons, sensors function, Glial cells,
Unit III: Neuro Anatomy II
Molecular and cellular organization of neuronal differentiation, characterization of
neuronal cells.
Unit IV: Neurophysiology
Conduction of impulses by neurons, Correlation of sensory functions.
Unit V: Neuropharmacology
Pharmaceutical mediator, released by neurons. Hormones and their effect on
neuronal function.
Unit VI: Neurological Disorders
Pathogenesis, Genetic basis of neurological disorders
Unit VII: Behavioural Science I
Neuronal mechanism of behaviour,
Unit VII: Behavioural Science II
Animal behaviour, Behaviour in various environments.
Reference:
1. A.B. Schiebel Neurobiology of higher cognitive function Guilford Press 1990,
(BT05453) PHYTOCHEMICALS AND HERBAL MEDICINE
Unit I: Crude Drugs
Crude Drugs – Scope & Importance, Classification (Taxonomical, Morphological Chemical,
Pharmacological); Cultivation, Collection & processing of Crude Drugs.
Unit II: Medicinal & Aromatic Plants
Cultivation and Utilization of Medicinal & Aromatic Plants in India. Genetics as applied to
Medicinal herbs.
Unit III: Tissue Culture of medicinal Plants
Plant Tissue Culture as source of medicines, Plant Tissue Culture for enhancing secondary
metabolite production (Withania somnifera, Rauwolfia serpentina, Catheranthus roseus,
Andrographis paniculata, Dioscorea sp.); Anticancer drugs, Biogenesis of
Phytopharmaceuticals.
Unit IV: Analysis of Phytochemicals
Methods of Drug evaluation (Morphological, Microscopic, Physical & Chemical). Preliminary
screening, Assay of Drugs – Biological evaluation / assays, Microbiological methods
Unit V: Chemical Methods of Analysis and Detection of Adulterants: Chemical estimations,
Spectrophotometry & Fluorescene analysis. Drug adulteration – Types of adulterants.
Unit VI: Types of Phytochemicals_I
Carbohydrates & derived products; Glycosides - extraction methods (Digitalis, Aloe,
Dioscorea,); Tannins (Hydrolysable & Condensed types); Volatile Oils - extraction methods
(Clove, Mentha);
UNIT VII : Types of Phytochemicals_II
Alkaloids - extraction methods (Taxus, Papaver, Cinchona); Flavonoids- extraction methods,
Resins- extraction methods.
Unit VIII: Applications of Phytochemicals
Application of phytochemicals in industryand healthcare; Biocides, Biofungicides,
Biopesticides.
Text Books:
1. Pharmacognosy, C. K. Kokate, A. P. Purohit & S. B. Gokhale (1996), Nirali Prakashan,
4th Ed.
2. Natural Products in medicine: A Biosynthetic approach (1997), Wiley.
References
1. Hornok,L. (ed.) (1992). Cultivation & Processing of Medicinal Plants, Chichister, U. K:
J. Wiley & Sons.
2. Trease & Evans, Pharmacognosy – William Charles Evans, 14th ed. (1989), Harcourt
Brace & Company.
Crude Drugs – Scope & Importance, Classification (Taxonomical, Morphological Chemical,
Pharmacological); Cultivation, Collection & processing of Crude Drugs.
Unit II: Medicinal & Aromatic Plants
Cultivation and Utilization of Medicinal & Aromatic Plants in India. Genetics as applied to
Medicinal herbs.
Unit III: Tissue Culture of medicinal Plants
Plant Tissue Culture as source of medicines, Plant Tissue Culture for enhancing secondary
metabolite production (Withania somnifera, Rauwolfia serpentina, Catheranthus roseus,
Andrographis paniculata, Dioscorea sp.); Anticancer drugs, Biogenesis of
Phytopharmaceuticals.
Unit IV: Analysis of Phytochemicals
Methods of Drug evaluation (Morphological, Microscopic, Physical & Chemical). Preliminary
screening, Assay of Drugs – Biological evaluation / assays, Microbiological methods
Unit V: Chemical Methods of Analysis and Detection of Adulterants: Chemical estimations,
Spectrophotometry & Fluorescene analysis. Drug adulteration – Types of adulterants.
Unit VI: Types of Phytochemicals_I
Carbohydrates & derived products; Glycosides - extraction methods (Digitalis, Aloe,
Dioscorea,); Tannins (Hydrolysable & Condensed types); Volatile Oils - extraction methods
(Clove, Mentha);
UNIT VII : Types of Phytochemicals_II
Alkaloids - extraction methods (Taxus, Papaver, Cinchona); Flavonoids- extraction methods,
Resins- extraction methods.
Unit VIII: Applications of Phytochemicals
Application of phytochemicals in industryand healthcare; Biocides, Biofungicides,
Biopesticides.
Text Books:
1. Pharmacognosy, C. K. Kokate, A. P. Purohit & S. B. Gokhale (1996), Nirali Prakashan,
4th Ed.
2. Natural Products in medicine: A Biosynthetic approach (1997), Wiley.
References
1. Hornok,L. (ed.) (1992). Cultivation & Processing of Medicinal Plants, Chichister, U. K:
J. Wiley & Sons.
2. Trease & Evans, Pharmacognosy – William Charles Evans, 14th ed. (1989), Harcourt
Brace & Company.
(BT05095) BIOPHARMACEUTICAL TECHNOLOGY
Unit I: Introduction to Pharmaceuticals
History & Definition of Drugs. Sources of Drugs - Plant, Animals, Microbes and Minerals.
Different dosage forms. Routes of drug administration.
Unit II: Pharmacodynamics
Physico-Chemical Principles, Pharmacodynamics- Mechanism of drug action, drug receptors,
and Physiological receptors: structural and functional families.
Unit III: Pharmacokinetics
Pharmacokinetics- Drug absortion, factors that affect the absortion of drugs, Distribution of
drugs, Biotransformation of drugs, Bioavailability of drugs.
Unit IV: Drug manufacturing processes I
Good manufacturing practices, manufacturing facilities, sources of Biopharmaceuticals,
Unit V: Drug manufacturing processes II
Production & analysis of Biopharmaceuticals.
Unit VI: Production of Biopharmaceuticals
Production of Therapeutic Proteins, Hormones, Cytokines - Interferons, Interleukins I & II,
Tumor Necrosis Factor (TNF); Nucleic acids.
Unit VII: Applications of Biopharmaceuticals
Role of Biopharmaceuticals in treatment of various health disorders
Unit VIII: Drug Delivery Systems, Biomaterials and their Applications
Controlled and sustained delivery of drugs. Biomaterial for the sustained drug delivery.
Liposome mediated drug delivery. Drug delivery methods for therapeutic proteins.
Reference:
1. Biopharmaceuticals: Biochemistry & Biotechnology, Gary Walsh (1998), John Wiley &
Sons Ltd.
2. Remington’s Pharmaceutical sciences, Mark Publications & Co.
3. Theory & Practice of Industrial Pharmacy, (3rd ed.) Leon Lachman, Lea &
Febiger (1986)
History & Definition of Drugs. Sources of Drugs - Plant, Animals, Microbes and Minerals.
Different dosage forms. Routes of drug administration.
Unit II: Pharmacodynamics
Physico-Chemical Principles, Pharmacodynamics- Mechanism of drug action, drug receptors,
and Physiological receptors: structural and functional families.
Unit III: Pharmacokinetics
Pharmacokinetics- Drug absortion, factors that affect the absortion of drugs, Distribution of
drugs, Biotransformation of drugs, Bioavailability of drugs.
Unit IV: Drug manufacturing processes I
Good manufacturing practices, manufacturing facilities, sources of Biopharmaceuticals,
Unit V: Drug manufacturing processes II
Production & analysis of Biopharmaceuticals.
Unit VI: Production of Biopharmaceuticals
Production of Therapeutic Proteins, Hormones, Cytokines - Interferons, Interleukins I & II,
Tumor Necrosis Factor (TNF); Nucleic acids.
Unit VII: Applications of Biopharmaceuticals
Role of Biopharmaceuticals in treatment of various health disorders
Unit VIII: Drug Delivery Systems, Biomaterials and their Applications
Controlled and sustained delivery of drugs. Biomaterial for the sustained drug delivery.
Liposome mediated drug delivery. Drug delivery methods for therapeutic proteins.
Reference:
1. Biopharmaceuticals: Biochemistry & Biotechnology, Gary Walsh (1998), John Wiley &
Sons Ltd.
2. Remington’s Pharmaceutical sciences, Mark Publications & Co.
3. Theory & Practice of Industrial Pharmacy, (3rd ed.) Leon Lachman, Lea &
Febiger (1986)
(BT05415) MOLECULAR MODELING & DRUG DESIGN
Unit I: Introduction to Molecular Modelling
Introduction to Molecular Modelling. What are models used for? Areas of application – Single
molecule calculation, assemblies of molecules. Reaction of the molecules. Drawbacks of
mechanical models as compared to graphical models. Co-ordinate systems two – matrix,
potential energy surface.
Unit III – Quantum Mechanics
Postulates of quantum mechanics, electronic structure calculations, ab initio, semi-empirical
and density functional theory calculations, molecular size versus accuracy. Approximate
molecular orbital theories.
Unit III: Empirical Force Field Models
Molecular Mechanisms, energy calculations, Bond stretch, angle bending, torsional term.
Electrostatic interaction- Van der waals interactions. Miscellaneous interaction.
Unit IV – Molecular Dynamics
Introduction, Molecular Dynamics using simple models. Dynamics with continuous potentials.
Constant temperature and constant dynamics. Conformation searching, Systematic search.
Applications to protein folding
Unit V – Comparative protein modeling
Modelling by Homology-the alignment, construction of frame work ,selecting variable regions,
side chain placement and refinement, validation of protein models –Ramchandran plot,
threading and ab initio modeling.
UNIT VI: Analog Based Drug Design
Introduction to QSAR. lead module, linear and nonlinear modeled equations, biological
activities, physicochemical parameter and molecular descriptors, molecular modelling in
drug discovery.
UNIT VII: Structure Based Drug Design
3D pharmacophores ,molecular docking, De novo Ligand design, Free energies and solvation,
electrostatic and non-electrostatic contribution to free energies.
UNIT VIII: Further applications on the design of new molecules
3D data base searching and virtual screening, Sources of data, molecular similarity and
similarity searching, combinatorial libraries – generation and utility,
TEXTBOOKS
1. Principles and applications of modelling by Leach
2. Molecular Modelling by Hans Pieter,Heltje & Gerd Folkens, VCH.
REFERENCES:
1. Chemical Applications of Molecular Modelling by Jonathan Goodman.
2. Computational Chemistry by Guy H, Grant & W. Graham Richards, Oxford University
Press.
Introduction to Molecular Modelling. What are models used for? Areas of application – Single
molecule calculation, assemblies of molecules. Reaction of the molecules. Drawbacks of
mechanical models as compared to graphical models. Co-ordinate systems two – matrix,
potential energy surface.
Unit III – Quantum Mechanics
Postulates of quantum mechanics, electronic structure calculations, ab initio, semi-empirical
and density functional theory calculations, molecular size versus accuracy. Approximate
molecular orbital theories.
Unit III: Empirical Force Field Models
Molecular Mechanisms, energy calculations, Bond stretch, angle bending, torsional term.
Electrostatic interaction- Van der waals interactions. Miscellaneous interaction.
Unit IV – Molecular Dynamics
Introduction, Molecular Dynamics using simple models. Dynamics with continuous potentials.
Constant temperature and constant dynamics. Conformation searching, Systematic search.
Applications to protein folding
Unit V – Comparative protein modeling
Modelling by Homology-the alignment, construction of frame work ,selecting variable regions,
side chain placement and refinement, validation of protein models –Ramchandran plot,
threading and ab initio modeling.
UNIT VI: Analog Based Drug Design
Introduction to QSAR. lead module, linear and nonlinear modeled equations, biological
activities, physicochemical parameter and molecular descriptors, molecular modelling in
drug discovery.
UNIT VII: Structure Based Drug Design
3D pharmacophores ,molecular docking, De novo Ligand design, Free energies and solvation,
electrostatic and non-electrostatic contribution to free energies.
UNIT VIII: Further applications on the design of new molecules
3D data base searching and virtual screening, Sources of data, molecular similarity and
similarity searching, combinatorial libraries – generation and utility,
TEXTBOOKS
1. Principles and applications of modelling by Leach
2. Molecular Modelling by Hans Pieter,Heltje & Gerd Folkens, VCH.
REFERENCES:
1. Chemical Applications of Molecular Modelling by Jonathan Goodman.
2. Computational Chemistry by Guy H, Grant & W. Graham Richards, Oxford University
Press.
(BT05262) FOOD SCIENCE & TECHNOLOGY
Unit I: Introduction To Food Processing
Biotechnology in relation to the food industry, nutritive value of food, and types of microorganisms
associated with food, its sources, types and behavior in foods.
Unit II: Food Preservation I
Bioprocessing of meat, fisheries, vegetables, dairy products, enzymes and chemicals
used in food processing,
Unit III: Food Preservation II
biochemical engineering for flavor and food production, cryopreservation, irradiated foods.
Unit IV: Fermented Food Products
Dairy products, non-beverage plant products, beverages and related products of baking.
Unit V: Quality Control
Quality control, case studies on Biotechnology in the evolution of food quality.
Unit VI: Food Spoilage & Food Borne Diseases
Food -borne infections & intoxications.
Unit VII: Food Microbiology I
Utilization of microorganisms in food Industry, Single cell protein, Neutraceuticals etc.,
Unit VIII: Food Microbiology II
Natural and artificial sweeteners and their role in controlling diseases and deficiencies.
TEXT BOOKS
1. Roger A., Gordan B., and John T., Food Biotechnology, 1989.
2. Frazier, Food Microbiology,
REFERENCES
1. George J.B., Basic Food Microbiology, CBS Publishers Distributors, 1987.
2. James M .J. Modern Food Microbiology, CBS Publishers & Distributors, 1987.
3. Lindsay, Willis Biotechnology, Challenges for the flavor and food Industries, Elsevier
Applied Science, 1988.
Biotechnology in relation to the food industry, nutritive value of food, and types of microorganisms
associated with food, its sources, types and behavior in foods.
Unit II: Food Preservation I
Bioprocessing of meat, fisheries, vegetables, dairy products, enzymes and chemicals
used in food processing,
Unit III: Food Preservation II
biochemical engineering for flavor and food production, cryopreservation, irradiated foods.
Unit IV: Fermented Food Products
Dairy products, non-beverage plant products, beverages and related products of baking.
Unit V: Quality Control
Quality control, case studies on Biotechnology in the evolution of food quality.
Unit VI: Food Spoilage & Food Borne Diseases
Food -borne infections & intoxications.
Unit VII: Food Microbiology I
Utilization of microorganisms in food Industry, Single cell protein, Neutraceuticals etc.,
Unit VIII: Food Microbiology II
Natural and artificial sweeteners and their role in controlling diseases and deficiencies.
TEXT BOOKS
1. Roger A., Gordan B., and John T., Food Biotechnology, 1989.
2. Frazier, Food Microbiology,
REFERENCES
1. George J.B., Basic Food Microbiology, CBS Publishers Distributors, 1987.
2. James M .J. Modern Food Microbiology, CBS Publishers & Distributors, 1987.
3. Lindsay, Willis Biotechnology, Challenges for the flavor and food Industries, Elsevier
Applied Science, 1988.
(BT05041) ANIMAL CELL SCIENCE AND TECHNOLOGY
Unit I:
Structure and Organization of animal cell; Equipments and materials for animal cell
culture technology; Primary and established cell line cultures; Introduction to the
balanced salt solutions and simple growth medium,
Unit II:
Brief discussion on the chemical, physical and metabolic functions of different
constituents of culture medium. Role of carbon dioxide. Role of serum and
supplements; Serum & protein free defined media and their application.
Unit III:
Measurement of viability and cytotoxicity; Biology and characterization of the cultured
cells, measuring parameters of growth;
Unit IV:
Basic techniques of mammalian cell culture in vitro; disaggregation of tissue and
primary culture, maintenance of cell culture; cell separation.
Unit V:
Cell synchronization; Cell cloning and micromanipulation; Cell transformation;
Application of animal cell culture; Scaling-up of animal cell culture.
Unit VI:
Stem cell cultures, embryonic stem cells and their applications; Cell culture based
vaccines, Somatic cell genetics.
Unit VII:
Organ and histotypic cultures; Measurement of cell death; Apoptosis;
Unit VIII:
Three dimensional culture and tissue engineering.
TEXT BOOKS:
1. Culture of Animal Cells, (3rd Edition), F1. Ian Froshney. Wiley-Liss.
2. Animal Cell Culture – Practical Approach, Ed. John R.W. Masters, OXFORD.
REFERENCES
1. Cell Culture Lab Fax. Eds. M. Butler & M. Dawson, Bios Scientific Publications
Ltd., Oxford.
2. Animal Cell Culture Techniques. Ed. Martin Clynes, Springer.
3. Methods in Cell Biology, Vol. 57, Animal Cell Culture Methods. Ed. Jenni P.
Mather and David Barnes. Academic Press.
4. Cell Growth and Division: A Practical Approach. Ed. R. Basega, IRL Press.
Structure and Organization of animal cell; Equipments and materials for animal cell
culture technology; Primary and established cell line cultures; Introduction to the
balanced salt solutions and simple growth medium,
Unit II:
Brief discussion on the chemical, physical and metabolic functions of different
constituents of culture medium. Role of carbon dioxide. Role of serum and
supplements; Serum & protein free defined media and their application.
Unit III:
Measurement of viability and cytotoxicity; Biology and characterization of the cultured
cells, measuring parameters of growth;
Unit IV:
Basic techniques of mammalian cell culture in vitro; disaggregation of tissue and
primary culture, maintenance of cell culture; cell separation.
Unit V:
Cell synchronization; Cell cloning and micromanipulation; Cell transformation;
Application of animal cell culture; Scaling-up of animal cell culture.
Unit VI:
Stem cell cultures, embryonic stem cells and their applications; Cell culture based
vaccines, Somatic cell genetics.
Unit VII:
Organ and histotypic cultures; Measurement of cell death; Apoptosis;
Unit VIII:
Three dimensional culture and tissue engineering.
TEXT BOOKS:
1. Culture of Animal Cells, (3rd Edition), F1. Ian Froshney. Wiley-Liss.
2. Animal Cell Culture – Practical Approach, Ed. John R.W. Masters, OXFORD.
REFERENCES
1. Cell Culture Lab Fax. Eds. M. Butler & M. Dawson, Bios Scientific Publications
Ltd., Oxford.
2. Animal Cell Culture Techniques. Ed. Martin Clynes, Springer.
3. Methods in Cell Biology, Vol. 57, Animal Cell Culture Methods. Ed. Jenni P.
Mather and David Barnes. Academic Press.
4. Cell Growth and Division: A Practical Approach. Ed. R. Basega, IRL Press.
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